Evaluation of the acute, sub-chronic and chronic oral toxicity, genetic toxicity, and safety of a Lomens-P0
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چکیده
منابع مشابه
Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments
Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reason of toxicity particularly in children and the elderly therefore, evaluation of the toxic effect...
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Objectives: The current preclinical study aimed at appraising the claim of anti diarrheal activity, acute and sub chronic oral toxicity of the polyherbal formulation Entoban to acknowledge its safety and efficacy. Methods: In order to investigate the antidiarrheal activity albino mice were treated with Entoban at doses of 2.5, 5, 10 mg/kg. For evaluation of acute toxicity the animals were treat...
متن کاملAcute and sub-acute oral toxicity of ethanol extract of Cassia fistula fruit in male rats
Objective: The plantCassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats. Materials and Methods: In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of...
متن کاملSub-Chronic Toxicity Study of Alpha-Cypermethrin in Rats
Alpha-cypermethrin (?-CP) a synthetic pyrethroid (type-II) insecticide, dissolved in dimethyl sulfoxide (DMSO-1ml) given consecutive daily orally for 60 days at 1/10LD50 (14.5mg/kg). The animals were sacrificed on day 61st. Biochemicals, cytochromeP450, b5 contents in liver along with antioxidant status, tissue residual concentration, and brain GABA level were studied. It increased the serum am...
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ژورنال
عنوان ژورنال: Toxicological Research
سال: 2021
ISSN: 1976-8257,2234-2753
DOI: 10.1007/s43188-021-00090-5